Work

Control of Protein Oligomerization Symmetry by Metal Coordination: C2 and C3 Symmetrical Assemblies through CuII and NiII Coordination

Year: 2009

Type: article

Abstract: We describe the metal-dependent self-assembly of symmetrical protein homooligomers from protein building blocks that feature appropriately engineered metal-chelating motifs on their surfaces. Crystallographic studies indicate that the same four-helix-bundle protein construct, MBPC-1, can self-assemble into C(2) and C(3) symmetrical assemblies dictated by Cu(II) and Ni(II) coordination, respectively. The symmetry inherent in metal coordination can thus be directly applied to biological self-assembly.

Source: Inorganic Chemistry

DOI: 10.1021/ic9001237

Authors: Eric N. Salgado, Richard A. Lewis, Susanne Mossin, Arnold L. Rheingold, F. Akif Tezcan

Institutions: Friedrich-Alexander-Universität Erlangen-Nürnberg, University of California San Diego

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G1037007809, MOLECULAR BIOPHYSICS TRAINING PROGRAM