A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence
Year: 2013
Type: article
Study design: Observational Study
Abstract: BACKGROUND: There are limited prospective studies of fish and meat intakes with risk of endometrial cancer and findings are inconsistent. METHODS: We studied associations between fish and meat intakes and endometrial cancer incidence in the large, prospective National Institutes of Health-AARP Diet and Health Study. Intakes of meat mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and benzo(a)pyrene (BaP) were also calculated. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: We observed no associations with endometrial cancer risk comparing the highest to lowest intake quintiles of red (HR=0.91, 95% CI 0.77-1.08), white (0.98, 0.83-1.17), processed meats (1.02, 0.86-1.21) and fish (1.10, 95% CI 0.93-1.29). We also found no associations between meat mutagen intakes and endometrial cancer. CONCLUSION: Our findings do not support an association between meat or fish intakes or meat mutagens and endometrial cancer.
Source: British Journal of Cancer
DOI: 10.1038/bjc.2013.252
Authors: H Arem, M J Gunter, A J Cross, A R Hollenbeck, R Sinha
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Funders: U.S. Department of Health and Human Services, U.S. Department of State, Pennsylvania Department of Health, Florida Department of Health, Emory University, Arizona Department of Health Services, Louisiana State University, Missouri Department of Health and Senior Services, Texas Department of State Health Services, National Institutes of Health, National Cancer Institute
OpenAlex ID: W2086770056