Work

Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division

Year: 2007

Type: article

Abstract: Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both populations. The asymmetric outcome of stem cell divisions can be specified by an oriented spindle and local self-renewal signals from the stem cell niche. Here we show that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line. The mother centrosome remains anchored near the niche while the daughter centrosome migrates to the opposite side of the cell before spindle formation.

Source: Science

DOI: 10.1126/science.1134910

Authors: Yukiko M. Yamashita, Anthony P. Mahowald, Julie R. Perlin, Margaret T. Fuller

Institutions: University of Chicago, Stanford Medicine, Stanford University

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: A Search for Genes that Regulate Stem Cells, Regulation of Stem Cell Self-Renewal and Differentiation