Work

Discriminative stimulus properties of midazolam are shared by a GABA-receptor positive steroid

Year: 1993

Type: article

Abstract: 3-Alpha-5-alpha-tetrahydrodeoxycorticosterone (alloTHDOC) is a 3-alpha ring A-reduced metabolite of deoxycorticosterone that has been shown to act via nongenomic mechanisms to modulate the GABAA receptor complex allosterically in vitro. Moreover, there are behavioral data consistent with the anxiolytic actions of GABA-receptor positive steroids. The drug discrimination paradigm was used in rats to demonstrate that effects of alloTHDOC are mediated by the GABAA receptor complex in the intact animal. In rats trained to discriminate 1.8 mg/kg of midazolam from saline, alloTHDOC substituted for the training stimulus.

Source: Pharmacology Biochemistry and Behavior

DOI: 10.1016/0091-3057(93)90229-m

Authors: Stephen I. Deutsch, John Mastropaolo

Institutions: United States Department of Veterans Affairs, Georgetown University, Veterans Health Administration, Washington DC VA Medical Center

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650