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CD34+CD38− and CD34+HLA−DR− contents in BMSC grafts correlate with short-term engraftment but have no influence on long-term hematopoietic recovery in patients who received autologous bone marrow transplantation

Year: 2005
Type: article
Study design: Observational Study
Abstract: Previous animal and human studies have demonstrated that the number of CD34+ subsets such as CD34+CD38− and CD34+HLA−DR− subsets in stem cell grafts is significantly associated with the speed of short-term hematopoietic reconstruction (SHR). The aim of this study was to determine whether these CD34+ subsets predict long-term hematopoietic reconstitution (LHR) in recipients of autologous bone marrow transplantation (ABMT). We have examined 53 lymphoma patients who received ABMTs to determine if total mononuclear cell dose, CFU-GM, CD34+ cell dose and CD34+ cell subsets (CD34+CD38− and CD34+HLA−DR−) correlate with both SHR and LHR. Time to neutrophil engraftment (TNE) and time to platelet engraftment (TPE) were used to measure SHR, and platelet count was used as an indicator of LHR at day 100 and 1 year post-ABMT. A total of 42 and 38 patients were analyzed at day 100 and 1 year post-transplant, respectively. Patients were excluded either because they were deceased or there was lack of follow-up data. Using a univariate unadjusted logistic regression analysis, all of the predictor variables were significantly associated with SHR. However, at day 100, only CFU-GM and CD34+ cell dose significantly predictedLHR. In addition, at 1 year post-ABMT, only CD34+ cell dose predicted LHR. CD34+ cell dose maintained its significance in multivariate analysis adjusting for age, sex, and disease. None of the CD34+ cell subsets predicted LHR.
DOI: 10.1016/j.bbmt.2004.12.197
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2086965723
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