Outcomes associated with a steroid-containing acute GVHD prophylaxis regimen for matched unrelated donor (MUD) hematopoietic stem cell transplantation
Year: 2006
Type: article
Study design: Clinical Trial
Abstract: Background: Previously reported randomized trials have yielded differing conclusions about the addition of steroids to GVHD prophylaxis for patients undergoing sibling allogeneic transplant. Prophylaxis with cyclosporine plus methotrexate after MUD transplant has a reported grade 2–4 acute GVHD incidence of 74%. MUD transplantation was initiated at OHSU in 1996 using a 3-drug combination of cyclosporine, methotrexate, and steroids in a single-arm prospective protocol to examine the incidence and severity of GVHD and survival.
Authors: B. Hayes-Lattin, J.F. Leis, P.T. Curtin, A. Dunn, E. Epner, W.H. Fleming, T. Kovacsovics, M.J. Mauro, M. Moore, A. Simic, N. Subbiah, R.T. Maziarz
Institution: Oregon Health & Science University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2087006978