New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity
Year: 2014
Type: review
Abstract: Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.
Source: CNS Spectrums
Institutions: University of Hertfordshire, University of Cambridge, Queen Elizabeth II Hospital, Hertfordshire Partnership University NHS Foundation Trust, Addenbrooke's Hospital, Cambridgeshire and Peterborough NHS Foundation Trust, Amsterdam UMC Location University of Amsterdam, Amsterdam Institute for Addiction Research, Arkin, University of Amsterdam, University of Cape Town, Utrecht University, University Medical Center Utrecht, Inserm, Centre for Psychiatry and Neuroscience, Université Paris Descartes, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Virginia Commonwealth University, Yale University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: National Center for Responsible Gaming, Yale University, Wellcome Trust, Academy of Medical Sciences, ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Center for Advancing Translational Sciences
Awards: G1261952208, G1461873485, The neural and neurochemical basis of compulsivity in humans and other animals., Social play behavior in periadolescent rats in relation to later drug abuse, Translational Center on Serotonin and Stimulant Addiction, Translational Addiction Sciences Center, Behavioral Technologies for Predicting HIV Risk, G3576777758, G4264098956, Neural mechanisms of CBT in cocaine dependence, fMRI of Craving in Addictions: Gender Differences, fMRI of Stress & Self-Control in Smoking & Obesity (7 of 14), Center for Clinical and Translational Research, Translational Research of Cocaine, Striatum, and Impulsivities, Substance Abuse Research - Medications Development Center, G7712394237, Behavioural and Clinical Neuroscience Institute (BCNI), G9000202091
OpenAlex ID: W2087042918