Work

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Year: 2006

Type: article

Abstract: Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm0601856

Authors: Christophe Biot, Wassim Daher, Natascha Chavain, Thierry Fandeur, Jamal Khalife, Daniel Dive, Erik De Clercq

Institutions: Centre National de la Recherche Scientifique, École Nationale Supérieure de Chimie de Lille, Inserm, Institut Pasteur, Rega Institute for Medical Research, Unité de Catalyse et Chimie du Solide, Institut National de la Recherche Agronomique, Pasteur Network

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2087251383

FWCI: 3.418

Cites: 35

Cited by: 324

Related to: 10