Expression of Mn‐Superoxide Dismutase Gene in Nontumorigenic and Tumorigenic Human Mammary Epithelial Cells
Year: 2004
Type: article
Abstract: Manganese superoxide dismutase (Mn-SOD), localized at the mitochondrial matrix, has the ability to protect cells against oxidative damage. It has been reported that low levels of Mn-SOD gene expression cause the development of certain kind of tumors. On the other hand, overexpression of Mn-SOD gene may play an important role in the development of cancer. In our study, we find that Mn-SOD activity was higher in nonaggressive (MCF-7) and aggressive (BT-549 and 11-9-14) breast cancer cell lines compared to that of nontumorigenic (MCF-12A and MCF-12F) mammary epithelial cell lines. We also observed an increased expression of Mn-SOD gene in cancerous cell lines. The elevated level of SOD activity in nonaggressive and aggressive breast epithelial cell lines was associated with some changes in nucleotide sequence.
Source: BioMed Research International
Institution: Meharry Medical College
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
Awards: SCORE Project at Meharry Medical College, AN OVER VIEW OF THE CONTINUATION OF THE WORK OF THE MUSTARD CONSORTIUM FOR THE USE OF THE FREE AND LIPOSOME ENCAPSULATED ANTIOXIDANTS AS A COUNTER ME, IS PERIPHERAL BENZODIAZEPINE RECEPTOR (PBR) GENE EXPRESSION INVOLVED IN BREAST CANCER SUPPRESSION BY DIETARY SOYBEAN PROTEIN
OpenAlex ID: W2087258338