Year: 2012
Type: article
Abstract: BACKGROUND: Disorders of the urinary tract represent a major cause of morbidity and impaired quality of life. To better understand the morphological events responsible for normal urinary tract development, we performed 3-D reconstructive analysis of developing mouse bladders in control, mgb-/-, and Fgfr2(Mes-/-) mice. RESULTS: Detrusor smooth muscle differentiation initiated in the bladder dome and progressed caudally with the leading edge extending down the right posterior surface of the bladder. Gender-specific differences in detrusor smooth muscle development were observed during early embryonic development. Bladder trigone morphology transitioned from an isosceles to equilateral triangle during development due to the preferential lengthening of the urethra to ureter distance. The primary defect observed in mgb-/- bladders was a significant reduction in detrusor smooth muscle differentiation throughout development. Deviations from normal trigone morphology correlated best with VUR development in Fgfr2(Mes-/-) mice, while alterations in intravesicular tunnel length did not. CONCLUSIONS: Multivariate morphometric analysis provides a powerful tool to quantify and assess urinary tract development.
Source: Developmental Dynamics
DOI: 10.1002/dvdy.23744
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G10732797, The Role of FGF Receptors in Lens Development, University of Pittsburgh Clinical and Translational Science Institute, Model of Congenital Obstructive Nephropathy-Biomarker & Therapeutic Development, University of Pittsburgh Clinical and Translational Science Institute, A Genetic Model of Urogenital Development & Obstruction, A genetic model of vesicoureteral reflux and reflux nephropathy
OpenAlex ID: W2087589276