Work

Regulatory gene network circuits underlying T cell development from multipotent progenitors

Year: 2011

Type: article

Abstract: Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function.

Source: WIREs Systems Biology and Medicine

DOI: 10.1002/wsbm.162

Authors: Hao Yuan Kueh, Ellen V. Rothenberg

Institution: California Institute of Technology

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute

Awards: Reverse engineering genetic network architecture of stem-cell/lymphocyte transiti, G1908350300, Lineage Commitment Mechanisms in Lymphoid Precursors, G428954799