Clofarabine ± Fludarabine With IV Busulfan And Allogeneic Stem Cell Transplantation For Relapsed, Refractory Myeloid Leukemia (ML) And MDS
Year: 2010
Type: article
Abstract: Clofarabine (Clo) is a nucleoside analog (NA) with improved antileukemic efficacy compared with Fludarabine (Flu), previously used with IV Busulfan (Bu) in reduced toxicity conditioning therapy for Allo-SCT. In vitro studies of [Clo+Flu+Bu] demonstrated a superior synergistic cytotoxicity compared with either [Clo+Bu] or [Flu+Bu].We have now investigated [Clo±Flu] with IV Bu in pretransplant conditioning.
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2087693871