Work

High Mobility Group Box 1 Protein as a Potential Drug Target for Infection- and Injury-Elicited Inflammation

Year: 2010

Type: article

Abstract: In response to infection or injury, a ubiquitous nucleosomal protein, HMGB1 is secreted actively by innate immune cells, and / or released passively by injured/damaged cells. Subsequently, extracellular HMGB1 alerts, recruits, and activates various innate immune cells to sustain a rigorous inflammatory response. A growing number of HMGB1 inhibitors ranging from neutralizing antibodies, endogenous hormones, to medicinal herb-derived small molecule HMGB1 inhibitors (such as nicotine, glycyrrhizin, tanshinones, and EGCG) are proven protective against lethal infection and ischemic injury. Here we review emerging evidence that support extracellular HMGB1 as a proinflammatory alarmin(g) danger signal, and discuss a wide array of HMGB1 inhibitors as potential therapeutic agents for sepsis and ischemic injury.

Source: Inflammation & Allergy - Drug Targets

DOI: 10.2174/187152810791292872

Authors: Shu Zhu, Wei Li, Mary Ward, Andrew Sama, Haichao Wang

Institutions: Northwell Health, Feinstein Institute for Medical Research, North Shore University Hospital, New York University, National University of Health Sciences

Language: English

Topic: Advanced Glycation End Products research

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences