Year: 2011
Type: article
Abstract: Cross-sectional analyses of naturally occurring spinal osteoarthritis (OA) in primates have shown that age and body mass are significant predictors, but whether or not these relationships hold true in longitudinal evaluations remains unclear. Because spinal OA manifests similarly in humans and monkeys and macaque monkeys age >3 times the rate of humans, macaque models offer opportunities for longitudinal study that are difficult in humans. Our objective was to characterize the longitudinal development over 11 years of spinal OA in 68 Macaca mulatta (41 males, 27 females, aged 11-32 years). Average disc space narrowing (DSN) and osteophytosis (OST) scores were computed for the thoracolumbar spine (T8-L7). Our longitudinal analyses confirmed the cross-sectional results: age and body mass (p < 0.001) significantly predicted 50% and 39% of the variability in OST and DSN, respectively. Rates of change in DSN, but not OST, were associated with age at first radiograph. This study represents the first long-term longitudinal assessment of OA in primates and establishes that the relationship among the covariates in the cross-sectional and longitudinal approaches is similar.
Source: Journal of Orthopaedic Research®
DOI: 10.1002/jor.21390
Institutions: University of Washington, University of Wisconsin–Madison
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: bronze
Awards: EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION, G286789154, EXTRAMURAL REGIONAL FACILITIES CONSTRUCTION, Osteoarthritis and Calorie Restriction, Caloric Restriction and Aging in Rhesus Monkeys, G832415928, Dietary Restriction and Aging in Rhesus Monkeys, G9000017745, Wisconsin National Primate Research Center Support
OpenAlex ID: W2087810340