Work

A Versatile Synthetic Extracellular Matrix Mimic via Thiol‐Norbornene Photopolymerization

Year: 2009

Type: article

Abstract: Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning.

Source: Advanced Materials

DOI: 10.1002/adma.200901808

Authors: Benjamin D. Fairbanks, Michael P. Schwartz, Alexandra E. Halevi, Charles R. Nuttelman, Christopher N. Bowman, Kristi S. Anseth

Institutions: University of Colorado Boulder, Howard Hughes Medical Institute

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute of Dental and Craniofacial Research

Award: Clickable Microgel Scaffolds for MSC Expansion and Delivery