Year: 1961
Type: article
Abstract: The principal processes of synthesis and metabolism for aromatic amines have been discussed in terms of their status in essential hypertension and in relation to alterations induced by enzyme inhibitors with hypotensive properties. From a practical standpoint, the clinical use of monoamine oxidase inhibitors and a decarboxylase inhibitor (α-methyldopa) approach the achievement of medical sympathectomy without prohibitive side effects. From a basic standpoint, use of these inhibitors as biochemical tools affords a new perspective into connections between aromatic amine metabolism and blood-pressure regulation. A combined pharmacological-biochemical approach in man will be an important phase of future investigations.
Source: Circulation Research
Author: ALBERT SJOERDSMA
Institution: National Institutes of Health
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2087907694