Work

The JAK-STAT pathway in hypertrophic stress signaling and genomic stress response

Year: 2012

Type: review

Abstract: The JAK-STAT signaling pathway plays a central role in transducing stress and growth signals in the hypertrophic heart. Unlike most signal transducers, JAKs and STATs signal in a number of different ways, both within the JAK-STAT pathway and in collaboration with other signaling pathways. In this review, we discuss how IL-6 activates cells lacking IL-6 receptors through trans-signaling and examine JAK-STAT pathway interaction with GPCR-linked pathways both within and between cells. Finally, we discuss recent studies showing how the JAK-STAT pathway can intersect with a general transcriptional regulatory mechanism to effect transcription of STAT-dependent stress response genes.

Source: JAK-STAT

DOI: 10.4161/jkst.20702

Authors: Michael A. Wagner, M.A.Q. Siddiqui

Institution: SUNY Downstate Health Sciences University

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: National Institutes of Health, Kasetsart University Research and Development Institute, National Heart, Lung, and Blood Institute

Award: Jak/Stat Signaling Pathway in Myocardial Hypertrophy