Regulatory T Cells Are Resistant to Cyclophosphamide (Cy) Through Expression of Aldehyde Dehydrogenase (ALDH) Upon Allogeneic Stimulation
Year: 2013
Type: article
Abstract: High-dose, post-transplantation Cy (PT/Cy) is a novel and effective strategy for preventing graft-versus-host disease (GVHD) after allogeneic blood or marrow transplantation (alloBMT). We previously reported that regulatory T cells (Tregs) are resistant to Cy in allogeneic reactions; activated Tregs (CD4+CD45RA-Foxp3+hi) are relatively increased 30 and 60 days after PT/Cy in vivo and both naïve (CD4+CD45RA+Foxp3+) and activated Tregs are resistant to cytotoxicity induced by activated Cy (mafosfamide) in mixed lymphocyte reactions (MLR) in vitro.
Institution: Johns Hopkins University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2088044938