Work

microRNA deficiency in pancreatic islet cells exacerbates streptozotocin-induced murine autoimmune diabetes

Year: 2010

Type: article

Abstract: Recent studies have demonstrated that gene expression is regulated not only by protein-coding genes, but also by nonprotein-coding small RNA molecules, microRNAs (miRNAs). miRNAs have emerged as important regulators involved in many biological processes, including cell proliferation and differentiation, apoptosis and metabolism and disease development. Here we report that specific miRNA deficiency in pancreatic islet cells exacerbates multiple low-dose streptozotocin-induced murine autoimmune type 1 diabetes, suggesting that miRNAs expressed in islet beta cells regulate their susceptibility to immune-mediated beta cell destruction.

Source: Cell Cycle

DOI: 10.4161/cc.9.15.12596

Authors: Qing-Sheng Mi, Hong-Zhi He, Zheng Dong, Carlos Isales, Li Zhou

Institutions: Henry Ford Health, Augusta University

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Juvenile Diabetes Research Foundation International