Perturbation of the immune network in herpes gestationis
Year: 1986
Type: article
Study design: Case Report
Abstract: We have studied the development of anti-idiotypic antibodies to HLA and of autoantibodies reacting with alloactivated T lymphoblasts in a woman with herpes gestationis (HG). This primigravida developed an elevated titer of anti-HLA antibodies, (Ab1), in association with a low titer and late appearance of anti-anti-HLA antibodies (Ab2). At delivery she developed only minimal levels of antibodies reacting with autologous T lymphoblasts (T1), sensitized against the immunizing HLA antigens of the child. Her serum reacted, however, with T lymphoblasts, primed in AMLC against autologous T blasts alloactivated in vitro against her husband (T2). Because healthy gravidae do not show such antibodies, it appears that they are peculiar to and may represent a perturbation of the idiotypic network in regard to the immune
Source: Human Immunology
Authors: Vincent R. Bonagura, Christine Rohowsky-Kochan, Elaine Reed, Averil Ma, Joan McDowell, Donald W. King, Nicole Suciu-Foca
Institutions: University of Chicago, Columbia University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,600
Funder: U.S. Public Health Service
Award: G207412729
OpenAlex ID: W2088489348