Work

Targeting the right regulatory T-cell population for tumor immunotherapy

Year: 2012

Type: article

Abstract: Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25(low) cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression.

Source: OncoImmunology

DOI: 10.4161/onci.20664

Authors: Vivian L. Weiss, Timothy H. Lee, Elizabeth M. Jaffee, Todd D. Armstrong

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913