Work

cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family

Year: 1996

Type: article

Abstract: The gene cul-1 (formerly lin-19) is a negative regulator of the cell cycle in C. elegans. Null mutations cause hyperplasia of all tissues. cul-1 is required for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway. Moreover, the mutant phenotype suggests that G1-to-S phase progression is accelerated, overriding mechanisms for mitotic arrest and producing abnormally small cells. Significantly, diverse aspects of cell fate and differentiation are unaffected in cul-1 mutants. cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast.

Source: Cell

DOI: 10.1016/s0092-8674(00)81267-2

Authors: Edward T Kipreos, Lois E Lander, John P Wing, Wei Wu He, Edward M Hedgecock

Institutions: Johns Hopkins University, Human Genome Sciences (United States)

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $11,400

Funder: National Institute of Neurological Disorders and Stroke