Work

Prophylactic irradiation in bronchogenic small cell anaplastic carcinoma. A comparative trial of localized versus extensive radiotherapy including prophylactic brain irradiation in patients receiving combination chemotherapy

Year: 1980

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: A total of 114 patients with bronchogenic small cell anaplastic carcinoma and staged as having regional disease all underwent combination chemotherapy consisting of CCNU, cyclophosphamide, and methotrexate. They were randomized to receive either radiotherapy to the primary tumor and regional lymph nodes (4000 rad) or extensive radiotherapy, which included the brain, adrenals, and upper retroperitoneal lymph nodes. Fifteen patients were free of disease after 18 months of chemotherapy and the treatment was discontinued. Only 3 patients subsequently relapsed. No difference was observed between the two groups of patients in median survival time, response rate, duration of response or relapse pattern, including the frequency of brain metastasis.

Source: Cancer

DOI: 10.1002/1097-0142(19800715)46:2<279::aid-cncr2820460210>3.0.co;2-w

Authors: Heine H. Hansen, Per Dombernowsky, Fred R. Hirsch, Mogens Hansen, Jorgen Rygård

Institution: Bispebjerg Hospital

Language: English

Topic: Lung Cancer Research Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Sundhed og Sygdom, Det Frie Forskningsråd, Medical Research Council