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The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation

Year: 2007

Type: conference-paper

Abstract: Guanine and G-rich oligonucleotides are known to self-assemble in the presence of a variety of cations to form higher ordered structures known as Gquadruplexes. We have synthesized a library of 8-aryl/heteroaryl-2'-deoxyguanosine derivatives (8ArGs) that are also able to self-assemble into quadruplex structures. We demonstrate that the properties of such quadruplexes can be modulated by the nature of the groups attached to the guanine base. These supramolecules are potentially useful in the development of self-assembled nanodevices.

Source: Nucleic Acids Symposium Series

DOI: 10.1093/nass/nrm020

Authors: V. Gubala, M. d. C. Rivera-Sanchez, G. Hobley, J. M. Rivera

Institution: University of Puerto Rico at Río Piedras

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2089030592

FWCI:

Cites:

Cited by: 3

Related to: 10