Work

Epigenetics of Inflammation, Maternal Infection, and Nutrition1–3

Year: 2015

Type: review

Abstract: Studies have demonstrated that epigenetic changes such as DNA methylation, histone modification, and chromatin remodeling are linked to an increased inflammatory response as well as increased risk of chronic disease development. A few studies have begun to investigate whether dietary nutrients play a beneficial role by modifying or reversing epigenetically induced inflammation. Results of these studies show that nutrients modify epigenetic pathways. However, little is known about how nutrients modulate inflammation by regulating immune cell function and/or immune cell differentiation via epigenetic pathways. This overview will provide information about the current understanding of the role of nutrients in the epigenetic control mechanisms of immune function.

Source: Journal of Nutrition

DOI: 10.3945/jn.114.194639

Authors: Kate J Claycombe, Catherine A Brissette, Othman Ghribi

Institutions: Agricultural Research Service, United States Department of Agriculture, Grand Forks Human Nutrition Research Center, University of North Dakota

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,200