Work

Mesoporous Silica Supraparticles for Sustained Inner‐Ear Drug Delivery

Year: 2014

Type: article

Abstract: Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model.

Source: Small

DOI: 10.1002/smll.201401767

Authors: Yajun Wang, Andrew K. Wise, Justin Tan, James W. Maina, Robert K. Shepherd, Frank Caruso

Institutions: The University of Melbourne, Fudan University, Bionics Institute

Language: English

Topic: Mesoporous Materials and Catalysis

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green