Work

Origins of Cystic Fibrosis Lung Disease

Year: 2015

Type: review

Abstract: Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator undermine many host defense systems by inhibiting the function of airway-surface liquid, causing flaws in mucociliary transport, and compromising other lung-protection mechanisms.

Source: New England Journal of Medicine

DOI: 10.1056/nejmra1300109

Authors: David A. Stoltz, David K. Meyerholz, Michael J. Welsh

Institutions: University of Iowa, Howard Hughes Medical Institute

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Heart, Lung, and Blood Institute