Work

Computational Design of a Collagen A:B:C-Type Heterotrimer

Year: 2011

Type: article

Abstract: We have successfully designed an A:B:C collagen peptide heterotrimer using an automated computational approach. The algorithm maximizes the energy gap between the target and competing misfolded states while enforcing a minimum target stability. Circular dichroism (CD) measurements confirm that all three peptides are required to form a stable, structured triple helix. This study highlights the power of automated computational design, providing model systems to probe the biophysics of collagen assembly and developing general methods for the design of fibrous proteins.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja205597g

Authors: Fei Xu, Sohail Zahid, Teresita Silva, Vikas Nanda

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institutes of Health

Award: Computational Design of a Synthetic Extracellular Matrix

OpenAlex ID: W2089352289

FWCI: 1.683

Cites: 33

Cited by: 61

Related to: 10