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An N-Terminal Amphipathic Helix in Dengue Virus Nonstructural Protein 4A Mediates Oligomerization and Is Essential for Replication

Year: 2013

Type: article

Abstract: Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral nonstructural protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.

Source: Journal of Virology

DOI: 10.1128/jvi.01900-12

Authors: Omer Stern, Yu-Fu Hung, Olga Valdau, Yakey Yaffe, Eva Harris, Silke Hoffmann, Dieter Willbold, Ella H. Sklan

Institutions: Tel Aviv University, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, University of California, Berkeley

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2089371826

FWCI: 8.159

Cites: 23

Cited by: 74

Related to: 10