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Asthma and Bronchial Hyperresponsiveness Linked to the XY Long Arm Pseudoautosomal Region

Year: 1998

Type: article

Study design: Observational Study

Abstract: We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.

Source: Genomics

DOI: 10.1006/geno.1998.5445

Authors: Kenneth J. Holroyd, Laura C. Martinati, Elisabetta Trabetti, Titia Scherpbier, Scott M. Eleff, Attilio L. Boner, Pier Franco Pignatti, Matthew B. Kiser, Carl R. Dragwa, Frank Hubbard, Christine D. Sullivan, Luigi Grasso, Carol J. Messler, Minxue Huang, Ying Hu, Nicholas C. Nicolaides, Kenneth H. Buetow, Roy C. Levitt

Institutions: Genaera (United States), University of Verona, Fox Chase Cancer Center, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,980

Funders: American Heart Association, National Institutes of Health, U.S. Public Health Service, National Center for Research Resources

Awards: G145407949, G2153585430, G268515340, Human Genetic Analysis Resource, G5195096164, G8333267328

OpenAlex ID: W2089393193

FWCI: 5.417

Cites: 11

Cited by: 62

Related to: 10