Year: 2002
Type: conference-abstract
Abstract: We have begun a small scale structural genomics project aimed at obtaining fold information for the set of sequence families comprising eukaryotic intracellular signaling domains, and exploiting that information to understand biological function and mechanism.The SMART database (http://smart.embl-heidelberg.de/smart) is the primary target list for the project.The practical issues of obtaining soluble and crystallizable representatives for each sequence family will be discussed.The question of how much can be learned about signaling mechanisms from elucidating the structure of one representative protein per sequence family will be considered.Examples illustrating issues of principle and practice will be drawn from recent work on VHS and other domains.
Author: J. Hurley
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2089420267