Work

l ‐Arginine prevents metabolic effects of high glucose in diabetic mice

Year: 2008

Type: article

Abstract: We tested the hypothesis that activation of the polyol pathway and protein kinase C (PKC) during diabetes is due to loss of NO. Our results show that after 4 weeks of streptozotocin-induced diabetes, treatment with L-arginine restored NO levels and prevented tissue accumulation of sorbitol in mice, which was accompanied by an increase in glutathiolation of aldose reductase. L-Arginine treatment decreased superoxide generation in the aorta, total PKC activity and PKC-beta(II) phosphorylation in the heart, and the plasma levels of triglycerides and soluble ICAM. These data suggest that increasing NO bioavailability by L-arginine corrects the major biochemical abnormalities of diabetes.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2008.06.039

Authors: Matthew B. West, Kota V. Ramana, Karin Kaiserova, Satish K. Srivastava, Aruni Bhatnagar

Institutions: University of Louisville, The University of Texas Medical Branch at Galveston

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze