A Symmetrical Fluorous Dendron‐Cyanine Dye‐Conjugated Bimodal Nanoprobe for Quantitative 19F MRI and NIR Fluorescence Bioimaging
Year: 2014
Type: article
Abstract: (19)F MRI and optical imaging are two powerful noninvasive molecular imaging modalities in biomedical applications. (19)F MRI has great potential for high resolution in vivo imaging, while fluorescent probes enable ultracontrast cellular/tissue imaging with high accuracy and sensitivity. A bimodal nanoprobe is developed, integrating the merits of (19)F MRI and fluorescence imaging into a single synthetic molecule, which is further engineered into nanoprobe, by addressing shortcomings of conventional contrast agents to explore the quantitative (19)F MRI and fluorescence imaging and cell tracking. Results show that this bimodal imaging nanoprobe presents high correlation of (19)F MR signal and NIR fluorescence intensity in vitro and in vivo. Additionally, this nanoprobe enables quantitative (19)F MR analysis, confirmed by a complementary fluorescence analysis. This unique feature can hardly be obtained by traditional (19)F MRI contrast agents. It is envisioned that this nanoprobe can hold great potential for quantitative and sensitive multi-modal molecular imaging.
Source: Advanced Healthcare Materials
Institutions: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Xiamen University, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Zhongda Hospital Southeast University, Southeast University, National Institute of Neurological Disorders and Stroke
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2089493602