Work

Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

Year: 2010

Type: article

Abstract: A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja1066459