Work

A pancreas specificity results from the combination of polyomavirus and Moloney murine leukemia virus enhancer.

Year: 1987

Type: article

Abstract: An infectious recombinant polyomavirus was constructed in which a regulatory region of its genome, the B enhancer region (nucleotides 5128-5265) has been replaced with the 72- or 73-base-pair repeat enhancer from the Moloney murine leukemia virus genome. We show that this recombinant polyomavirus displays a strong tissue specificity for the pancreas of mice. This organ was not permissive for either the parental polyomavirus, which is predominantly kidney and salivary gland specific, or the Moloney murine leukemia virus, which is lymphotropic. This result indicated that tissue specificity can be achieved by a combination of apparently modular elements. Some of the implications of a modular mechanism of tissue specificity are considered.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.84.2.449

Authors: R Rochford, B A Campbell, L P Villarreal

Institution: University of California, Irvine

Language: English

Topic: Polyomavirus and related diseases

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, U.S. Public Health Service, National Cancer Institute, National Institute of General Medical Sciences