Work

Failure to demonstrate an advantage in combining sulphamethoxazole with trimethoprim in an experimental model of urinary infection

Year: 1974

Type: article

Abstract: Co-trimoxazole was found to have a predominantly bacteriostatic effect upon 28 urinary isolates of Enterobacteriaceae in nutrient broth and was never bactericidal in artificially infected urine. The components of co-trimoxazole were tested individually and trimethoprim was found to be at least as effective as co-trimoxazole in nutrient broth and in urine. Trimethoprim alone produced some bactericidal effect in urine but this was antagonized by sulphamethoxazole. Laboratory tests for evaluating these drugs may give a misleading impression of their activity in vivo. Further clinical comparisons should therefore be made between trimethoprim and cotrimoxazole to determine when trimethoprim should be used in preference to the combination.

Source: Journal of Clinical Pathology

DOI: 10.1136/jcp.27.8.619

Authors: J. D. Anderson, R. W. Lacey, E. L. Lewis, M. A. Sellin

Institution: University of Bristol

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2089661225