Structure and Function of Photolyase and in Vivo Enzymology: 50th Anniversary
Year: 2008
Type: review
Abstract: Photoreactivation is the reversal of the harmful effects of far-UV radiation (200–300 nm) on organisms, such as growth delay, mutation, cell death, and cancer, by concomitant or subsequent exposure of the organism to near-UV/blue light (300–500 nm). The two major lesions induced in DNA by UV light are cyclobutane pyrimidine dimers (Pyr<>Pyr2 or CPD), which constitute ∼80–90% of the photoproducts, and pyrimidine-pyrimidone (6-4) photoproducts (Pyr[6-4]Pyr), which account for the 10–20% of the UV lesions.
Source: Journal of Biological Chemistry
Author: Aziz Sancar
Institution: University of North Carolina at Chapel Hill
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
Awards: G342085443, G9000020968
OpenAlex ID: W2089724322