Work

CD137 stimulation enhances the vaccinal effect of anti-tumor antibodies

Year: 2014

Type: article

Abstract: Some evidence suggests that monoclonal antibodies (mAb) can induce an adaptive immune response against tumor cells ("vaccinal effect"). Recently, we have shown that an anti-CD137 mAb can enhance the "vaccinal effect" of an anti-tumor mAb (cetuximab), thereby transforming a passive, monoclonal, short-term immunotherapy into an active, polyclonal, long-lasting immune response.

Source: OncoImmunology

DOI: 10.4161/21624011.2014.941740

Authors: Roch Houot, Holbrook Kohrt

Institutions: Inserm, Centre Hospitalier Universitaire de Rennes, Stanford Medicine, Stanford University

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913