Work

The CD40–CD154 system in anti-infective host defense

Year: 1997

Type: review

Abstract: Research in the past few years has documented significant advances in our understanding of the CD40-CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this system in the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.

Source: Current Opinion in Immunology

DOI: 10.1016/s0952-7915(97)80100-8

Authors: Iqbal S Grewal, Persephone Borrow, Eric G Pamer, Michael BA Oldstone, Richard A Flavell

Institutions: Howard Hughes Medical Institute, Yale University, Scripps Research Institute

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,410