Work

Comparison of quantitative magnetic resonance imaging and positron emission tomography between patients with dementia of the alzheimer type and multi-infarct dementia

Year: 1992

Type: article

Abstract: Alzheimer's dementia (AD) and multi-infarct de mentia (MID) are both associated with expansion of the cerebrospinal fluid (CSF) spaces and changes in cerebralglucose metabolism (1). Magnetic resonance imaging (MRI) has been very useful in qualitatively differentiating patients with MID from those with AD by the characteristic multiple diffuse white matter lesions indicative of multiple infarctions (2-4). Matsuzawa (5) showed that the limbic system was the primary focus of the dementia syndrome in AD. Quantitative MR analysis of AD patients has corrob orated qualitative findings showing CSF volumes in AD patients when compared to age-matched controls (6). There have been a number of 18F-deoxyglucose positron emission tomography (FOG-PET) studies comparing AD and MID. Patients with AD have de creased average whole brain cerebral glucose metab olism (CMRGIc), most prominent in the parietal and temporal lobes, especially with increasing severity of dementia (7-9). Patients with MID have PET images that show scattered focal areas of hypometabolism (10) corresponding to the multiple lesions seen on MRI. No studies were reported that compared CMRGIc in patients with MID and AD. More recent ly, investigators have suggested that CMRGIc values might require correction for brain atrophy, since From the Division of Nuclear Med icine, Hospital of the University of Pennsylvania, Philadelphia, PA, U.S.A. Presented at the 16th Salzburg Conference of the Cere brovascular Research Group of the World Federation of Neurology, which was a satellite symposia of the Second World Congress of Stroke sponsored by the International Stroke Society, Washington, DC, September 8-12,1992. Address correspondence and reprint requests to Dr. A. Alavi at Division of Nuclear Medicine, Hospital of the Uni versity of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, U.S.A.

Source: Journal of Stroke and Cerebrovascular Diseases

DOI: 10.1016/s1052-3057(10)80051-5

Authors: Abass Alavi, A. Newberg, E. Souder, M. Reivich

Institution: Hospital of the University of Pennsylvania

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,170