Work

Inhibition of the B Cell by CD22: A Requirement for Lyn

Year: 1998

Type: article

Abstract: Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.187.5.807

Authors: Kenneth G.C. Smith, David M. Tarlinton, Gina M. Doody, Margaret L. Hibbs, Douglas T. Fearon

Institutions: The Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research, University of Cambridge, Ludwig Cancer Research

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases