Work

Interferons as gene activators: Close linkage of two interferon-activatable murine genes

Year: 1988

Type: article

Abstract: Previously we have identified a mouse genomic clone (clone 5) which specifies the 5' flanking region and the 5' terminal exon of an interferon-activatable gene (202 gene). Here, we show that about 5 kb upstream from this flanking region in clone 5 there occurs a 3' terminal region of a second interferon-activatable gene (203 gene). The two genes are transcribed in the same direction. Segments from the 203 gene can be hybridized to a set of five interferon-inducible RNAs. The 203 mRNAs are induced about 15-fold in interferon-treated Ehrlich ascites tumor cells.

Source: Virology

DOI: 10.1016/0042-6822(88)90142-0

Authors: Daniel A. Engel, Jay Snoddy, Elena Toniato, Peter Lengyel

Institution: Yale University

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,160

Funders: National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases