Year: 2006
Type: review
Abstract: The prevalence of conduction disturbances, particularly left bundle branch block (LBBB), is strongly correlated with age and with the presence of cardiovascular disease. LBBB has been reported to affect approximately 25% of the heart failure (HF) population and it is likely that the deleterious role of such conduction disorders in the progression to HF has been underestimated. The purpose of this article is to review the data from the literature indicating that LBBB may have a causative role, mediated through the resulting intra-ventricular asynchrony, in the deterioration of cardiac function and the development of cardiac remodelling and HF. It also aims to address the potential for future clinical therapies for this conduction disorder.
Institutions: Inserm, Centre Hospitalier Régional et Universitaire de Nancy, Hôpital Jeanne d'Arc, Stavanger University Hospital, University Medical Center Groningen, Universitätsklinikum Aachen, RWTH Aachen University, Rigshospitalet, Associazione Nazionale Medici Cardiologi Ospedalieri, University of Ferrara, Fondazione Salvatore Maugeri, Pitié-Salpêtrière Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2090483197