CMV Specific T Cells Prevent Progression From Low to High Level Viremia in D+R+ But Not D-R+ Patients
Year: 2011
Type: article
Study design: Observational Study
Abstract: Cytomegalovirus (CMV) reactivates (becomes detectable in blood) in most seropositive hematopoietic cell transplant (HCT) recipients. In some reactivating patients, low level viremia (< 50,000 DNA copies/ml plasma, ie, less than our institutional threshold for preemtive therapy) progresses to high level viremia or CMV disease, which is potentially fatal. We hypothesized that low level viremia progresses in patients with low specific T cell counts and spontaneously resolves in patients with high specific T cell counts.
Authors: M. Hoegh-Petersen, L. Roa, Y. Liu, F. Zhou, A. Ugarte-Torres, P. Louie, K. Fonseca, F. Khan, J. Storek
Institutions: University of Calgary, Alberta Health Services
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2090787122