Work

Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

Year: 2015

Type: article

Abstract: In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.

Source: Chemical Communications

DOI: 10.1039/c5cc01869b

Authors: M. Kavruk, O. Celikbicak, V. C. Ozalp, B. A. Borsa, F. J. Hernandez, G. Bayramoglu, B. Salih, M. Y. Arica

Institutions: Middle East Technical University, Hacettepe University, Altınbaş University, Biogipuzkoa Health Research Institute, Gazi University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2090849723

FWCI: 3.268

Cites: 41

Cited by: 86

Related to: 10