Work

Small‐Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics

Year: 2010

Type: review

Abstract: David and Goliath: Small-molecule inhibitors of the ERK signaling pathway (shown) and their potential as novel antitumor agents are discussed in detail within this Minireview. Specifically, the direct and indirect inhibition of ERK through ATP-competitive and non-ATP-competitive modes of action is highlighted.

Source: ChemMedChem

DOI: 10.1002/cmdc.201000354

Authors: Jeremy L. Yap, Shilpa Worlikar, Alexander D. MacKerell, Paul Shapiro, Steven Fletcher

Institution: University of Maryland, Baltimore

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute