Work

Effectiveness of a six-drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children

Year: 1985

Type: article

Abstract: Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six-drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T-cell lymphoblastic lymphomas.

Source: Cancer

DOI: 10.1002/1097-0142(19850815)56:4<738::aid-cncr2820560406>3.0.co;2-o

Authors: Bruce M. Camitta, Stephen J. Lauer, James T. Casper, Phyllis A. Kirchner, Larry E. Kun, Herbert W. Oechler, Stuart E. Adair

Institutions: Children's Hospital of Wisconsin, Medical College of Wisconsin

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2090983387

FWCI: 1.131

Cites: 20

Cited by: 13

Related to: 10