Work

Type B Coxsackieviruses and Their Interactions with the Innate and Adaptive Immune Systems

Year: 2010

Type: review

Abstract: Coxsackieviruses are important human pathogens, and their interactions with the innate and adaptive immune systems are of particular interest. Many viruses evade some aspects of the innate response, but coxsackieviruses go a step further by actively inducing, and then exploiting, some features of the host cell response. Furthermore, while most viruses encode proteins that hinder the effector functions of adaptive immunity, coxsackieviruses and their cousins demonstrate a unique capacity to almost completely evade the attention of naive CD8(+) T cells. In this artcle, we discuss the above phenomena, describe the current status of research in the field, and present several testable hypotheses regarding possible links between virus infection, innate immune sensing and disease.

Source: Future Microbiology

DOI: 10.2217/fmb.10.101

Authors: Christopher C Kemball, Mehrdad Alirezaei, J Lindsay Whitton

Institution: Scripps Research Institute

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Scripps Research Institute, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases