Work

Effect of Alkylureas on the Polymerization of Hemoglobin S

Year: 1974

Type: article

Abstract: Alkylureas (methyl-, ethyl-, propyl-, and butyl-) can inhibit both the gelation of deoxyhemoglobin S and red cell sickling without denaturation of the hemoglobin or intrinsic alteration of its oxygen affinity. This effect is directly proportional to the length of the alkyl chain and substantiates the importance of hydrophobic interactions in the polymerization of hemoglobin S. In addition, it opens the possibility that further systematic investigations with these compounds will help quantitate the role of hydrophobic interactions in this system so as to further our understanding of the polymerization of deoxyhemoglobin S.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.71.12.4718

Authors: Danek Elbaum, Ronald L. Nagel, Robert M. Bookchin, Theodore T. Herskovits

Institutions: Albert Einstein College of Medicine, Fordham University

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2091017982

FWCI: 3.134

Cites: 33

Cited by: 41

Related to: 10