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Carcinoma of type II pneumocytes. PAS staining as a screening test for nuclear inclusions of surfactant specific apoprotein

Year: 1982

Type: article

Abstract: Bronchioloalveolar carcinomas (n = 15) and other primary lung carcinomas (n = 9) were studied by PAS staining. The bronchioloalveolar carcinoma group contained three cases of carcinomas of type II pneumocytes. Cytoplasmic staining with PAS was most intense in mucus secreting carcinomas. Carcinomas of type II pneumocytes could not be differentiated from other tumors on the basis of cytoplasmic PAS staining. However, PAS positive nuclear "inclusion" were seen only in the three carcinomas of type II pneumocytes. The study indicates that PAS staining, though nonspecific, may serve as a screening test for carcinomas of type II pneumocytes by highlighting the nuclear inclusions of surfactant specific apoprotein.

Source: Cancer

DOI: 10.1002/1097-0142(19820901)50:5<946::aid-cncr2820500524>3.0.co;2-t

Authors: Gurmukh Singh, Sikandar L. Katyal, Chikao Torikata

Institutions: University of Pittsburgh, Keio University

Language: English

Topic: Lung Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2091112241

FWCI: 3.096

Cites: 8

Cited by: 22

Related to: 10